Journal article
Numerical and experimental investigations of the flow–pressure relation in multiple sequential stenoses coronary artery
S Li, C Chin, V Thondapu, EKW Poon, JP Monty, Y Li, ASH Ooi, S Tu, P Barlis
International Journal of Cardiovascular Imaging | SPRINGER | Published : 2017
Abstract
Virtual fractional flow reserve (vFFR) has been evaluated as an adjunct to invasive fractional flow reserve (FFR) in the light of its operational and economic benefits. The accuracy of vFFR and the complexity of hyperemic flow simulation are still not clearly understood. This study investigates the flow–pressure relation in an idealised multiple sequential stenoses coronary artery model via numerical and experimental approaches. Pressure drop is linearly correlated with flow rate irrespective of the number of stenosis. Computational fluid dynamics results are in good agreement with the experimental data, demonstrating reasonable accuracy of vFFR. It was also found that the difference between..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported with supercomputing resources provided by the Phoenix HPC service at the University of Adelaide. This research was undertaken with the assistance of resources provided by the Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0210 at its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia. The authors also acknowledge the financial support of the Australian Research Council under ARC Linkage Project LP120100233 and the National Natural Science Foundation of China (Grant Numbers 31500797 and 81570456) and the National Key Research and Development Program of China (Grant Number 2016YFC0100500). Dr. Tu acknowledges the support by The Program for Professor of Special Appointment (eastern Scholar) at Shanghai Institutions of Higher Learning. The Shanghai Pujiang Program (No. 15PJ1404200).